Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
Identifieur interne : 000894 ( Main/Exploration ); précédent : 000893; suivant : 000895Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
Auteurs : Nancy J. Rothwell [Royaume-Uni] ; Giamal Luheshi [Royaume-Uni] ; Sylvie Toulmond [Royaume-Uni]Source :
- Pharmacology and Therapeutics [ 0163-7258 ] ; 1996.
English descriptors
- Teeft :
- Antagonist, Astrocyte, Biol, Bram, Cytokine, Dinarello, Endogenous, Endotoxin, Febrile responses, Giulian, Glia, Glial, Glial cells, Growth factors, Immunol, Interleukin, Ischaemia, Kluger, Krueger, Lipopolysaccharide, Luheshi, Mediator, Mrna, Necrosis, Nerve growth factor, Neurodegeneration, Neuronal, Neuronal damage, Neurones, Neurosci, Neurotrophic, Neurotrophins, Nmda, Pharmacol, Physiol, Pyrogen, Pyrogenic, Receptor, Receptor antagonist, Recombinant, Relton, Rothwell, Strijbos, Thermogenesis, Toulmond, Trends pharmacol, Tumor necrosis factor.
Abstract
Abstract: Numerous cytokines and their receptors have been identified in the brain, where they act as mediators of host defence responses and have direct effects on neuronal and glial function. Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. The recent discovery of specific inhibitors of cytokine synthesis, release, or action may offer significant therapeutic benefit.
Url:
DOI: 10.1016/0163-7258(95)02033-0
Affiliations:
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Le document en format XML
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Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. The recent discovery of specific inhibitors of cytokine synthesis, release, or action may offer significant therapeutic benefit.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Manchester</li></region><settlement><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rothwell, Nancy J" sort="Rothwell, Nancy J" uniqKey="Rothwell N" first="Nancy J." last="Rothwell">Nancy J. Rothwell</name></region><name sortKey="Luheshi, Giamal" sort="Luheshi, Giamal" uniqKey="Luheshi G" first="Giamal" last="Luheshi">Giamal Luheshi</name><name sortKey="Toulmond, Sylvie" sort="Toulmond, Sylvie" uniqKey="Toulmond S" first="Sylvie" last="Toulmond">Sylvie Toulmond</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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